Reader Notes Uncommonly Large Dose of Glycopyrrolate

Michael D. Russell, MD, PhD

To the Editor:

Regarding the previous letter to the editor by Dr. Li in the Winter 2008-2009 issue of this Newsletter, glycopyrrolate and dexamethasone come in vials with concentrations of 0.4 mg/ml and 4 mg/ml, respectively, for a good reason. Typical doses of glycopyrrolate and dexamethasone are 0.01 mg/kg and 0.1 mg/kg respectively. A 15-kg girl would more commonly be given dexamethasone 1.5-2 mg IV; 20 mg is excessive and not commonly given in that dose.

Michael D. Russell, MD, PhD
Tacoma, WA