Circulation 94,429 • Volume 27, No. 1 • Summer-Spring 2012   Issue PDF

New Anticoagulants Present New Challenges

Rajnish K. Gupta, MD

In the last decade, several new anticoagulation medications have become available on the market. Table 1 summarizes several of these new drugs as well as relevant pharmacologic data. Primarily these agents are being used for stroke prevention in patients with atrial fibrillation or for the prevention of venous thromboembolic events (VTE) in the perioperative period. The appeal of many of these agents to our colleagues and patients is their ease of administration, with once or twice daily dosing, and the lack of need for therapeutic monitoring. The newest agents are orally administered as well.

However, for anesthesiologists, these drugs are often under-recognized as potential hazards during urgent operations and procedures such as regional anesthesia. In particular, patients are at high risk of developing epidural hematoma and neurologic complications during neuraxial anesthesia. Becoming familiar with the names, mechanism of action, and predicted half-life of these drugs is critical to safe anesthesia practice.

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This information is intended only to increase awareness about the new anticoagulation medications appearing on the market and not to serve as peer-reviewed recommendations for patient care. Refer to the American Society of Regional Anesthesia guidelines on anticoagulation for more comprehensive consensus statements regarding patient management.

Dr. Gupta is Assistant Professor and Associate Director of Adult Acute Pain Service Vanderbilt University, Nashville, TN


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