The APSF Newsletter again owes great thanks to those who made production and distribution of this publication possible in 2000. At AstraZeneca Pharmaceuticals LP in Wilmington, Delaware, administrative coordination and support are provided by Ms. Liz Whalen. Production support comes through AstraZeneca from Graphic Arts Services, Inc. of Wilmington, Delaware. The production of the more than 60,000 copies of each issue merits the great appreciation of all APSF members and other readers.Readers of the APSF Newsletter as well as the APSF organization as a whole also express heartfelt thanks to the Agilent (formerly Hewlett-Packard) Company and its Clinical Systems Business Unit for their continuing support through the contribution of computer equipment used in the Newsletter production process and in support of the APSF web page on the Internet.