Opioid Prescribing: Methadone Risk Mitigation
by Joan M. Christie, MD
Methadone is a synthetic opioid with an exceptionally prolonged elimination half-life. It is modestly priced and has a unique ability among opiates to block NMDA receptors, leading to a resurgence in its use for chronic pain.1 In 2007, for example, over 4 million prescriptions were issued for methadone, most for chronic, non-malignant pain. Even though it has an association with torsades de pointes ventricular tachycardia, methadone has been dubbed the “darling of the pain management community.”. . .[more]
The Official Journal of the Anesthesia Patient Safety Foundation
The Anesthesia Patient Safety Foundation Newsletter is the official publication of the nonprofit Anesthesia Patient Safety Foundation and is published quarterly in Wilmington, Delaware. Annual contributor cost: Individual–$100, Corporate–$500. This and any additional contributions to the Foundation are tax deductible. © Copyright, Anesthesia Patient Safety Foundation, 2011.
The opinions expressed in this Newsletter are not necessarily those of the Anesthesia Patient Safety Foundation. The APSF neither writes nor promulgates standards, and the opinions expressed herein should not be construed to constitute practice standards or practice parameters. Validity of opinions presented, drug dosages, accuracy, and completeness of content are not guaranteed by the APSF.
APSF Executive Committee:
Robert K. Stoelting, MD, President; Nassib G. Chamoun, Vice President; Jeffrey B. Cooper, PhD, Executive Vice President; George A. Schapiro, Executive Vice President; Matthew B. Weinger, MD, Secretary; Casey D. Blitt, MD, Treasurer; Sorin J. Brull, MD; Robert A. Caplan, MD; David M. Gaba, MD; Patricia A. Kapur, MD; Lorri A. Lee, MD; Robert C. Morell, MD; A. William Paulsen, PhD; Richard C. Prielipp, MD; Steven R. Sanford, JD; Mark A. Warner, MD. Consultants to the Executive Committee: John H. Eichhorn, MD; Maria Magro, CRNA, MS, MSN.
Newsletter Editorial Board:
Robert C. Morell, MD, Co-Editor; Lorri A. Lee, MD, Co-Editor; Sorin J. Brull, MD; Joan Christie, MD; Jan Ehrenwerth, MD; John H. Eichhorn, MD; Susan R. Fossum, RN; Steven B. Greenberg, MD; Rodney C. Lester, PhD, CRNA; Glenn S. Murphy, MD; Karen Posner, PhD; Andrew F. Smith, MRCP, FRCA; Wilson Somerville, PhD; Jeffery Vender, MD.
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